Train

Take the train Sc at the station Praha Hlavni Nadrazi .1

The journey takes approximately 2 h 22 min. Ticket price is about 8–14 EUR. The travel distance is 175 km.

Carrier is Czech Railways (ČD).

Book

Get off at the Marianske Lazne
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Drive

In a rental car

The drive will take 1 h 47 min.. The distance between Prague and Mariánské Lázně is 170 km. You will use 14 liters of gasoline at a cost of €18.2.

See on this site which rental company has the best deal.

Find hotel deals and discounts up to 20% in Mariánské Lázně at Booking